I have this stubborn starting material that is quite reluctant to react the way I need it to, under typical Sonogashira conditions with propargyl alcohol (PdCl2(PPh3)2, CuI, pyrrolidine, heat).
I am unfortunately not at liberty to disclose the exact structure, but what I can say is that the arylbromide is quite electron-rich (FGs [...]
Spring was in the air today. Serious tidying up was in place. Unlabeled samples were trashed. Flasks, bottles and retorts were subjected to all kinds of solvents, then dried under the sun. Cobwebs were torched. At the end of the day, I even arsed myself to install electric lighting.
Yes, I find it so much [...]
After unpacking today’s deliveries, one bottle stood out. The upside-down fish is creepy as hell. Also, I love the other GHS symbol that says ‘no GHS symbol’ – akin to the liar paradox – poetic almost.
So… what do you think this could be? Hint: It is not fentanyl, sarin, [...]