I just felt like showing off a little here tonight. These are the before and after pictures:

recrystallization

Upon work-up, many grams of a viscous oil were obtained, contaning a mixture of diastereomers (whose exact composition I cannot go into). My God, did I struggle to get the one isomer I so highly desired out of this soup. Chromatography was a nightmare and I had been struggling so hard for such a long time with this one. Suddenly, lo and behold, I stumbled upon a recrystallization method that actually worked. Not only did I get white crystals, a wet dream itself for many among our kind, but the single diastereomer that precipitated out was – once in a lifetime – the desired one. With the correct absolute stereochemistry in place. The first crop gave 70% yield of perfectly pure material. This was a good day, indeed.

 

4 Responses to NOTHING is as rewarding as a successful recrystallization

  1. Freda says:

    That is IMPRESSIVE! More importantly, what was this recrystallisation method that you have stumbled upon? Would be too glad to have a go. All too pleasing to get beautiful white crystals out of a crude oil like that.

  2. anon says:

    if you can’t distill it or recrystallise you shouldn’t be making it. column chromatography is not only inelegant it is also incredibly incredibly boring.

  3. jjlw says:

    As an undergrad, doing simple crystallization in lab is already so exciting despite having our hands held all the time. I can’t imagine the feeling of getting the compound you want after so much work!

  4. Stater of the Obvious says:

    Hey that looks almost exactly like the S-enantiomer of Taniguchi lactone.

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