Yay, I did live to see it! The very reaction I requested here, a little more than a year ago. Check out this fantastico, shmantastico cross-coupling, in the latest issue of the best journal on Earth:
Org. Lett. 2012, ASAP (DOI: 10.1021/ol3029109)
Do you see what I see? I see:
- A straight TMS-arene in a palladium catalyzed cross coupling — FINALLY!
- C-H activation. Always nice. More of that, thank you.
- Selectivity for the beta-position of thiophenes. (Rare shit, trust me.)
- R = everything. Cool.
- No weird catalysts or ligands. Huge plus.
…and I haven’t even read the paper yet 🙂
This from the graphical abstract. Now I know what to read tonight.