In 2003, give or take a year or so, a fellow grad student showed me this hilarious paper. I’m 85% sure it was in JOC and by one of the top dogs; I mean Katritzky or someone like that. It was usually long, even for a full paper. One of the paragraphs towards the end […]
Just to be redundantly clear: The following artwork is a mere work of fiction (and some alone time with Photoshop).
But seriously, wouldn’t it be awesome if some of our dusty old applications were spiced up with a couple of Web 2.0 functions?
- Hey SciFinder, the time has come for you to […]
3. Kurt Vonnegut
2. Dolph Lundgren
In 1982 Hans “Dolph” Lundgren graduated with a M.Sc. in chemical engineering, […]
A thermal runaway is the chemical equivalency of a nuclear meltdown. It is scary stuff, believe me. Here is a horrible, real-life example:
Clearly, these guys had no idea of what forces they were dealing with. Going directly from 1 L to a 2500 gallon (roughly 10000 L) scale is bananas. Especially with […]
After work-up, LCMS, GCMS and HNMR agree: Pure desired product. Woho!
New reaction type, new mechanism (which we don’t fully understand yet), new conditions. A one-step alternative to what usually takes three or four steps, arriving at a very attractive heterocycle.
I can’t go into any details right now, but we are working on […]
A couple of days ago, I – this page – was retweeted by Nature Chemistry. Proof:
I was shocked and flattered, of course, and I am pretty confident that this marks the height of my career. If you feel like following in Nature Chemistry’s footpath (who would rather not?), follow @SyntheticRemark on […]
I hereby admit that it was ages ago since I even looked at a MSDS, and I presume I am not the only one. Why? It is certainly not because I do not care about the safety of myself or others, because I really do, but because these so called documents are – in the […]
Amides are pretty tough to reduce down to their corresponding amines. Typically, you hydrogenate at high temperature and pressure or use LAH, borane, dissolving metals and stuff like that, under – obviously – pretty harsh conditions. Good old March (5th ed., ISBN: 0471585890) says: “The reaction is more difficult than the reduction of most […]
If I say free, useful and open source – do you say Microsoft? I didn’t think so. But this time around, it looks like Microsoft has pulled its act together and released a really useful Word add-in for chemists called Chem4Word.
The press release is found here, and the download link and a […]
The nitro group is inarguably the mother of all functional groups. It has character. It is not dull.
Take a plain organic compound and stick a nitro group to it, and things get just a little more interesting. Lots of cool compounds have nitro groups in them, for a variety of purposes. The notorious […]