Amides are pretty tough to reduce down to their corresponding amines. Typically, you hydrogenate at high temperature and pressure or use LAH, borane, dissolving metals and stuff like that, under – obviously – pretty harsh conditions. Good old March (5th ed., ISBN: 0471585890) says: “The reaction is more difficult than the reduction of most [...]
If I say free, useful and open source – do you say Microsoft? I didn’t think so. But this time around, it looks like Microsoft has pulled its act together and released a really useful Word add-in for chemists called Chem4Word.
The press release is found here, and the download link and a [...]
The nitro group is inarguably the mother of all functional groups. It has character. It is not dull.
Take a plain organic compound and stick a nitro group to it, and things get just a little more interesting. Lots of cool compounds have nitro groups in them, for a variety of purposes. The notorious [...]
Today, Justus von Liebig’s account was permanently suspended and his fanpage for Synthesis Remarks deleted. Moreover, it appears as if no-one can “like” this page on Facebook. Rats.
For the time being, friends, it looks like we will have to do without Facebook.
Even though large tracts of the Internet and many old and [...]
Albert Niemann (1834–1861) was a German chemist. He is best known for the discovery of cocaine (1.) (or rather its isolation in pure form, from coca leaves) (DOI:10.1002/ardp.18601530202), a feat which earned him his Ph.D. degree.
The same year, in 1860, during “experiments with ethylene and sulfur dichloride” (you know, casually mixing [...]
I was delighted to discover that Justus von Liebig has returned from the dead and created a Facebook Fanpage for this page, available here:
Nah, but the idea is to try to keep this page a little on the formal side (DOI:s and shit), and we’ll take YouTube clips and stuff like that [...]
I was just struck by the grim realization that I probably never will get the Nobel Prize in Chemistry. I have thus been forced to come up with a Plan B for immortality. Find attached my application for eternal life in the form of a Name Reaction. I think I have what [...]
LSD, Krazy Glue, radioactivity, Teflon, Viagra, X-rays, the planet Uranus, penicillin, corn flakes, gravity – the list of things we would never have heard of if we didn’t occasionally luck out as scientists is virtually endless.
Serendipity is roughly “good luck in making unexpected and fortunate discoveries”. A good deal of the most amazing [...]
Nomenclature is a bitch. Element 74 (W) in the periodic table is tungsten in English. Since “tung sten” is Swedish for “heavy stone”, and since the element was discovered by a Swedish 18th century chemist (Carl Willhelm Scheele), the etymology appears pretty uncomplicated. Until you realize that in contemporary Swedish, element 74 is [...]
Despite the fact that the dictionary says…
Dropwise (adverb): one drop at a time
… and we will phrase it like this…
“With good stirring at -78 ºC under argon, a solution of n-butyl lithium in hexanes (2.5M, 37.5 mmol, 15 mL) was added dropwise over 20 mins.”
… this is what actually happened…