This recent mini-review neither has a written nor a graphical abstract (at least not at the time of writing), but its kick-ass title forced me to download and check it out.
M. McLaughlin, S. Paul, A. Remirez, P. Richardson, J. M. Muhuhi, A. Zlota, J. Knight
“Some Items of Interest to Process R & […]
The substance is 3,4-diflurothiophene, CAS # 19259-15-5. Let there be no confusion; the compound is small, but the picture is big.
When you look in the literature, you find
A lot of computational chemistry Some who magically had it as a starting material One or two lengthy preparations and miserable atom economy
Long story […]
Yay, I did live to see it! The very reaction I requested here, a little more than a year ago. Check out this fantastico, shmantastico cross-coupling, in the latest issue of the best journal on Earth:
Org. Lett. 2012, ASAP (DOI: 10.1021/ol3029109)
Do you see what I […]
6. Michael Barclay: “What do you think about chemistry Nobel prizes going to more biologically related fields? A detriment to our subject or an example of how chemistry can cross a variety of fields?”
(The questions were collected in this previous post.)
1. Chemjobber: “What’s the biggest clusterfuck of a project you’ve been involved with, and how did you make it worse?”
There was this project which involved a super-active compound, according to the primary and cell assays, and met stab data were decent. The compound was […]
As long as I’m not breaking any laws, confidentially agreements or someone’s heart, I promise to give each and every of the ten (10) first commentators to this post, on any topic, a frank and extensive reply; full disclosure. (Let’s say at least five sentences each.)
Don’t be shy – this can be fun! […]
Every now and then, company representatives contact me in hope that I mention their products or services on this page. In fact, mostly in exchange for nothing. I usually don’t even bother to reply, as I assume I’m just one name among many on their email list.
The other day however, I got an email […]
Today, I got a nice little surprise in my mail inbox – the physical kind (they still exist!). My former diploma worker, almost a decade ago now… damn, has leveled up and will be defending his thesis in a couple of weeks from today.
I love the title! Exactly what you would expect from the […]
Yup, my last solid connection with Big Pharma is hereby officially dead and buried. Period. Just now, I was going to sign a couple of documents, so I grabbed the nearest pen I could find, which happened to be an old one from a former employer of mine.
See what happened with your own […]