I’ve been working late nights for some time now on transferring a relatively large catalog of chemicals (>1200) from an Excel database into a webpage for a client. I have relied heavily on ChemDraw for Excel. Nomenclature is, as always, a bitch. When working with these quantities, you cannot manually go [...]
Say you need to silylate something, like an alcohol or a ketone. Boy, have I got the recipe!
Dissolve 1.25 eq dry sodium iodide in dry acetonitrile. Dissolve your starting material in hexanes (pentane or heptane, all good). Don’t worry if everything doesn’t dissolve properly; solubility will increase during the course of the reaction. [...]
It typically doesn’t take more than 10 minutes to get the reaction going, from weighing out the starting materials until the first promising bubbles appear. Almost any solvent is good. I prefer low-boiling alcohols; methanol or ethanol. [...]
We were watching Goldfinger (1964) the other day. Again. You gotta love the real Bond movies. Anyways, in the opening scene, about 1 minute and 47 seconds into the movie, I was able to snap a frame with quite a lot of (medicinal) chemistry in it. The whole shot lasts for about two seconds and [...]
I have been cleaning up the front page, as you may have noticed. So, where has all the content gone – are all the links gone? The RSS feeds? Worry not. All the stuff that used to sit in the sidebars have been moved into a separate page called “Good Stuff.” Check it out.
Lots of people in chemistry complain about how slow the publication process is. I am by no means an exception. I personally hate the time between the acceptance letter and the first public appearance of the paper. It can take months! When you just want to go out and tell the world… (Not to mention [...]
Listen up, kids. If you absolutely must get high, at least do yourself the favor of sticking to good old weed. Grass has been around a while, some 5,000 years or more, and should something go wrong while you puff away, the medical profession and people around you know pretty well how to deal with [...]
I’ve been collecting, organizing and combining RSS feeds back and forth for quite some time. I like the concept of being fed the latest in as few clicks as possible.
It just struck me that some of my favorites might interest you as well. Look to the left! Update: Look under “Good Stuff.” There they [...]
Hey guys, I could really use your help. I have devised this wonderful novel route that gives desired in much fewer steps than before – with a small caveat. The final compound has a tin too many. As I cannot show you exact structures, this image will have to suffice. R is actually lots of [...]
Important message to all computational chemists: DO NOT MIX COMPUTERS AND CHEMICALS
It may end bad. At least it did so in our hand for this keyboard when exposed to an unintentional splash of dichloromethane.
Someone please call 911… wait.