The substance is 3,4-diflurothiophene, CAS # 19259-15-5. Let there be no confusion; the compound is small, but the picture is big.
When you look in the literature, you find
A lot of computational chemistry Some who magically had it as a starting material One or two lengthy preparations and miserable atom economy
Long story […]
Yay, I did live to see it! The very reaction I requested here, a little more than a year ago. Check out this fantastico, shmantastico cross-coupling, in the latest issue of the best journal on Earth:
Org. Lett. 2012, ASAP (DOI: 10.1021/ol3029109)
Do you see what I […]
6. Michael Barclay: “What do you think about chemistry Nobel prizes going to more biologically related fields? A detriment to our subject or an example of how chemistry can cross a variety of fields?”
(The questions were collected in this previous post.)
1. Chemjobber: “What’s the biggest clusterfuck of a project you’ve been involved with, and how did you make it worse?”
There was this project which involved a super-active compound, according to the primary and cell assays, and met stab data were decent. The compound was […]
As long as I’m not breaking any laws, confidentially agreements or someone’s heart, I promise to give each and every of the ten (10) first commentators to this post, on any topic, a frank and extensive reply; full disclosure. (Let’s say at least five sentences each.)
Don’t be shy – this can be fun! […]
Every now and then, company representatives contact me in hope that I mention their products or services on this page. In fact, mostly in exchange for nothing. I usually don’t even bother to reply, as I assume I’m just one name among many on their email list.
The other day however, I got an email […]
Today, I got a nice little surprise in my mail inbox – the physical kind (they still exist!). My former diploma worker, almost a decade ago now… damn, has leveled up and will be defending his thesis in a couple of weeks from today.
I love the title! Exactly what you would expect from the […]
Yup, my last solid connection with Big Pharma is hereby officially dead and buried. Period. Just now, I was going to sign a couple of documents, so I grabbed the nearest pen I could find, which happened to be an old one from a former employer of mine.
See what happened with your own […]
So, you’re a scientist, huh? Ph.D. and God knows what…
You know, this is your girlfriend’s/wife’s, parents’, (CSI watching) non-scientist friends’ mental image of your work place
…while it in fact looks more like
(Peter, I am sorry. You’re an awesome chemist, really. But it was kind of difficult […]