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Awesome functional group transformation #2

By drfreddy On January 25th, 2011 · Leave a Comment

You have the aryl bromide. You need the corresponding aniline. Buchwald-Hartwig isn’t working.

Been there. Done that. Got the t-shirt.

What to do? Check this out! A catalytic Ullman amination. No need for stochiometric amounts of copper. Ligand and solvent free. Table 3, entry 1, for instance.

JOC 2011, Article ASAP (Available here.)

The […]

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Legal Highs: The Dark Side of Medicinal Chemistry

By drfreddy On January 6th, 2011 · Leave a Comment

Professor David Nichols, one of the World’s greatest authorities on novel psychoactive compounds, has just published an amazingly clear and honest column in the latest issue of Nature (doi:10.1038/469007a). Grab it here. It is a must-read.

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