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Poll: Between 1901 and 2011, which Nobel Prize in Chemistry required the LEAST amount of work?

By drfreddy On August 30th, 2011 · 9 Comments

Which was it?

Here is a list of the contestants. In the comment field below, state name, year and a brief justification (using not more than 12 words).

Hint: 1965, R. B. Woodward is wrong.

I am not insinuating someone took a shortcut or […]

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Amide reductions: The saga continues

By drfreddy On August 29th, 2011 · 4 Comments

Remember that I congratulated Matthias Beller and co-workers for selectively reducing amides in the presence of anything else? Only caveat: The amides absolutely needed to be tertiary.

Only a week or so after posting (I swear to all holy things I had no idea know Beller was incoming), I attended his lecture, and […]

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Five flavors of flood

By drfreddy On August 28th, 2011 · 2 Comments

The sad truth is that according to my latest figures, less than 4 % of the comments here are legit. The rest is spam. Spam, spam, spam.

One thing that I find particularly amusing is how incompetent the average spammer is. This makes it easy to automatically filter off the by-product, so to speak, […]

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“Comic Sans—The official font of Med Chem”

By drfreddy On August 24th, 2011 · 5 Comments

Comic Sans is without a doubt and for very good reasons the most hated of all fonts ever created. Even the sorry creator, typographer Vincent Connare, sympathizes with the world-wide movement to ban it. If still in doubt, look here, Continue Reading →

Slow down, Phil

By drfreddy On August 22nd, 2011 · 29 Comments

An open letter to Phil S. Baran
(Spotify users, cue this before reading further)

Dear Phil,

On behalf of all mankind: Would you please slow down? We mortals have no chance to keep up with you. It is not funny anymore. We need a break.

[…]

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LinkedIn. Seriously. WTF were you thinking?

By drfreddy On August 21st, 2011 · 1 Comment

I use LinkedIn a lot. I like LinkedIn. In my current position, I collaborate with many people across the world, and I think LinkedIn is a great interface for networking; connecting and keeping in touch with colleagues. Until just a couple of days ago.

Listen. I am not against paying for a good service. […]

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Climate change? My thoughts.

By drfreddy On August 21st, 2011 · 15 Comments

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My hate-love relationship with the Stille coupling

By drfreddy On August 18th, 2011 · 3 Comments

The problem I have with the Stille coupling is that it always works. How do you like the sound of that? When Suzuki, Kumada, Negishi fail one after the other with certain troublesome substrates, Stille always comes to the rescue. Yields may vary, yields do vary, but there is always […]

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Look to the right ———>

By drfreddy On August 17th, 2011 · 5 Comments

I have added several new links during the past few week, to useful chemistry tools and to other fantastic blogs. Rather than to go into details, I recommend you explore them yourself. Look to the right!

I am always on the lookout for more, so if you think there is a resource, tool, page, […]

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Plain boronic is plain moronic

By drfreddy On August 15th, 2011 · 6 Comments

As coupling partners in Suzuki type reactions, plain arylboronic acids and esters belong in the past, together with a few other things (Figure 1).

Figure 1. Outdated occurrences: Dinosaurs, mullets, SCART cables, wasp waists and phenylboronic acids; requiescat in pace

So much progress in the […]

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