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Poisons and poverty

By drfreddy On November 19th, 2011 · 1 Comment

“Chemists are a strange class of mortals, impelled by an almost maniacal impulse to seek their pleasures amongst smoke and vapour, soot and flames, poisons and poverty, yet amongst all these evils I seem to live so sweetly that I would rather die than change places with the King of Persia.”

Johann Joachim […]

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ChemFeeds cuts the crap out of titles

By drfreddy On November 18th, 2011 · 2 Comments

As I have said many times before, I totally recommend ChemFeeds for getting a quick and comprehensible overview of the most recent Chemistry literature. I can’t even begin to imagine how much work is needed behind the scenes to make the whole thing work. Two thumbs up!

The page does however suffer […]

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Is IQ inversely proportional to happiness? Can it be this simple?

By drfreddy On November 16th, 2011 · 16 Comments

Do you think it is like this? A linear correlation between intelligence and happiness.

Or is it like this? A local minimum for semi-bright individuals?

Would love to hear your theories on the matter. Help me out here. I can’t make up my mind over the two scenarios. For Linus Pauling’s and Bertrand […]

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Pyridine!

By drfreddy On November 15th, 2011 · 3 Comments

I remember at one point having a (review?) paper called “Pyridine!” in my collection. Love that title. I can’t remember who wrote it, what year it was from or what it contained. Now I can’t find it again, because SciFinder and Google Scholar seem to ignore the exclamation mark in text based searches. If you […]

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The stinkiest name reaction

By drfreddy On November 13th, 2011 · 5 Comments

I would be most surprised if anyone of you had heard of the Willgerodt-Kindler reaction before. It stinks, literally and figuratively. Don’t get me wrong, the reaction works really well, but that is also its actual problem. The desired products are extremely undesired, if you know what I am saying. I have […]

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Total synthesis of bromobenzene

By drfreddy On November 10th, 2011 · 9 Comments

An international team of scientists herein wish to report on a seminal EAS functionalization approach to unearth a mono-substituted benzene (1), tentatively named bromobenzene.

Scheme 1. Synthesis of bromobenzene

It is noteworthy that the depicted synthesis is strictly linear. According to preliminary results, the addition of a catalytic amount of Lewis acid is […]

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Diesel fuel? Seriously.

By drfreddy On November 8th, 2011 · 57 Comments

Help a fellow chemist out here, I’m drawing a complete blank. Could somebody provide a hint about the actual, molecular composition of diesel fuel?

My new car runs on it and I want to know what it is. To begin with, I can’t even find a satisfactory and unambiguous definition of diesel. It is […]

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Stereochemical agony

By drfreddy On November 5th, 2011 · 5 Comments

— Judging from this 1H-NMR, it looks like your product was epimerized during work-up.
— No. No. That’s not true. The LCMS is flawless. That’s impossible!
— Search your feelings, this coupling constant, you know it is a cis configuration.
— No! Noooooooooooo!

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The one compound

By drfreddy On November 1st, 2011 · Leave a Comment

I hate November. In the search for something illustrative, this turned up.

Say hello to novembichin (1).

As a nitrogen analog of mustard gas, the mother of war agents, this one should be equally nasty. Novembichin is not something you would want to spill on your hands. The immediate effects would […]

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The way of the dragon

By drfreddy On October 23rd, 2011 · 8 Comments

In 1972 Bruce Lee defeated Chuck Norris (here) and team Far East has been winning ever since. China is on a monumental roll. If we fast-forward to present day and for example summarize the table of contents for one recent issue of Synlett, […]

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