If your local dealer insists on cutting your dope with sugar, you should be aware that there is a fix for it now.

Specifically, if the sugar is pure D-ribose and the desired dope is (—)-cocaine, which is the natural stuff indeed, you can convert the former into product with excellent stereoselectivity and an impressive overall yield.


Org. Lett. 2011, 13, 2916-2919. (DOI: 10.1021/ol2009686)

Nah… but seriously, I really enjoyed reading this paper. Apart from the awesome chemistry presented throughout, and do check it out if you like total synthesis, the fact that the authors spend most of page one talking about how bad cocaine is, and then directly proceed to the details of its preparation, made my day.

Scheme 2 is like a text book. Great stuff.


4 Responses to Cocaine from sugar

  1. […] Synthetic Remarks blog tells of a new study about how to convert sugar into […]

  2. […] Sweet synthesis turns ribose into cocaine. [Org. Lett. via Synthetic Remarks] […]

  3. Aeden Smith-Ahearn says:


    My name is Aeden Smith-Ahearn. I love your site! You guys do a great job.

    Anyways, I have a proposition that could be helpful.

    I do drug treatments in Mexico with Ibogaine. It’s completely different than traditional rehab. I would love to write an article for your site about Ibogaine. It could get you some very unique traffic and pull in a few more views for you as well as help me in my end goal.

    Let me know if that’s something that would interest you. I write exceptionally high quality articles so I know I can get you something you would like.

    For reference, here is an article I did for Addiction Blog.


    Thanks for your consideration!

    Aeden Smith-Ahearn
    [email protected]

  4. Aeden Smith-Ahearn says:


    My name is Aeden Smith-Ahearn, and I’m the the Content Coordinator for Experience Ibogaine.

    I thought you would find our latest report on addiction interesting.

    Our analysts here at Experience created a report and US map that you can read here, detailing the most prevalent addictions by individual states.

    We were surprised by the results to say the least. Some were very interesting, and others were a little worrisome. Here are a few of the findings:

    Pornography and Sex Addiction – Easily among the highest ranking searches were those regarding pornography and sex addiction. This trend continues to grow.
    Opiate, Heroin, and Prescription Pill Addiction – This is the most troubling information that we uncovered. The sheer fact that many states had their own specific opiate addiction (such as Hydrocodone, Vicodin, Methadone, and Tramadol) shows just how unique and widespread this problem is.
    Social Media and Technology Addiction – Another “on the rise” addiction category seems to revolve around cell phones, social media, video games, and other technology-based addictions.
    Marijuana Addiction – Many states scored relatively high on marijuana addiction. However, newly legalized states, Oregon and Washington, scored extremely high.
    Nicotine Addiction – In many states, cigarette, nicotine, and vaping addictions have very high search volumes.
    Other interesting addictions – California continues to deal with crack addiction. Sugar and food addictions are also a massive problem. Maryland scored very high for cheese addiction–slightly comical yet still relevant.

    Pretty interesting!

    Feel free to cover our findings and/or use one of the US state maps we created. If you have questions for me, feel free to respond, or, if you would like me to write a breakdown article for your site, I would be more than happy to.

    You can find our shared Google file here. It contains the map that you can use should you decide to cover this topic.


    Aeden Smith-Ahearn
    Treatment Coordinator
    Experience Ibogaine
    [email protected]

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