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Reaction #86 worked!

By drfreddy On April 3rd, 2011 · 9 Comments

After work-up, LCMS, GCMS and HNMR agree: Pure desired product. Woho!

New reaction type, new mechanism (which we don’t fully understand yet), new conditions. A one-step alternative to what usually takes three or four steps, arriving at a very attractive heterocycle.

I can’t go into any details right now, but we are working on […]

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The height of my career

By drfreddy On March 30th, 2011 · Leave a Comment

A couple of days ago, I – this page – was retweeted by Nature Chemistry. Proof:

I was shocked and flattered, of course, and I am pretty confident that this marks the height of my career. If you feel like following in Nature Chemistry’s footpath (who would rather not?), follow @SyntheticRemark on […]

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Material Safety Data Sheets – Who the hell is responsible for their utter uselessness?

By drfreddy On March 28th, 2011 · 11 Comments

I hereby admit that it was ages ago since I even looked at a MSDS, and I presume I am not the only one. Why? It is certainly not because I do not care about the safety of myself or others, because I really do, but because these so called documents are – in the […]

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Mild and selective amide reduction (in the presence of pretty much anything else)

By drfreddy On March 21st, 2011 · 7 Comments

Amides are pretty tough to reduce down to their corresponding amines. Typically, you hydrogenate at high temperature and pressure or use LAH, borane, dissolving metals and stuff like that, under – obviously – pretty harsh conditions. Good old March (5th ed., ISBN: 0471585890) says: “The reaction is more difficult than the reduction of most […]

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Microsoft does the unexpected: Chem4Word

By drfreddy On March 18th, 2011 · 1 Comment

If I say free, useful and open source – do you say Microsoft? I didn’t think so. But this time around, it looks like Microsoft has pulled its act together and released a really useful Word add-in for chemists called Chem4Word.

The press release is found here, and the download link and a […]

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A homage to the nitro group

By drfreddy On March 17th, 2011 · 7 Comments

The nitro group is inarguably the mother of all functional groups. It has character. It is not dull.

Take a plain organic compound and stick a nitro group to it, and things get just a little more interesting. Lots of cool compounds have nitro groups in them, for a variety of purposes. The notorious […]

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So long, Facebook. It was good while it lasted!

By drfreddy On March 16th, 2011 · 4 Comments

Today, Justus von Liebig’s account was permanently suspended and his fanpage for Synthesis Remarks deleted. Moreover, it appears as if no-one can “like” this page on Facebook. Rats.

For the time being, friends, it looks like we will have to do without Facebook.

 

Even though large tracts of the Internet and many old and […]

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German chemist discovers cocaine, then mustard gas, then dies—at age 26

By drfreddy On March 10th, 2011 · 3 Comments

Albert Niemann (1834–1861) was a German chemist. He is best known for the discovery of cocaine (1.) (or rather its isolation in pure form, from coca leaves) (DOI:10.1002/ardp.18601530202), a feat which earned him his Ph.D. degree.

The same year, in 1860, during “experiments with ethylene and sulfur dichloride” (you know, casually mixing […]

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New fanpage up and running!

By drfreddy On March 8th, 2011 · Leave a Comment

I was delighted to discover that Justus von Liebig has returned from the dead and created a Facebook Fanpage for this page, available here:

facebook.com/syntheticremarks

Nah, but the idea is to try to keep this page a little on the formal side (DOI:s and shit), and we’ll take YouTube clips and stuff like that […]

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An application for immortality

By drfreddy On March 5th, 2011 · 4 Comments

Dear All,

I was just struck by the grim realization that I probably never will get the Nobel Prize in Chemistry. I have thus been forced to come up with a Plan B for immortality. Find attached my application for eternal life in the form of a Name Reaction. I think I have what […]

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